Revolutionary blood test that could predict how long you'll live, what ailments you'll get - and how fast you'll age -
A revolutionary new blood test could tell you how long you will live, and how quickly you will age.
Scientists have discovered a chemical ‘fingerprint’ in the blood that may provide clues to an infant's health and rate of ageing near the end of life.
The discovery raises the prospect of a simple test at birth that could help doctors stave off the ravages of disease in old age.
It could lead to the development of powerful new treatments for age related conditions such as bone problems and heart disease.
Scientists identified 22 metabolites, small molecules linked to metabolism, that may be useful indicators of how we can expect to grow old.
One in particular, linked to a range of traits including lung function, bone density, blood pressure and cholesterol levels, was singled out by the researchers.
It is also strongly associated with birth weight - itself a known determinant of healthy ageing.
Levels of this metabolite, C-glyTrp, could reflect accelerated ageing in later adulthood, the scientists believe.
Higher levels of the molecule were associated with lower weight at birth in comparisons between pairs of identical twins.
Since identical twins share the same genes, this suggests that levels of the metabolite are altered by nutrition or different conditions in the womb.
Study leader Professor Tim Spector, from King's College London, said: ‘Scientists have known for a long time that a person's weight at the time of birth is an important determinant of health in middle and old age, and that people with low birth weight are more susceptible to age related diseases.
‘So far the molecular mechanisms that link low birth weight to health or disease in old age had remained elusive, but this discovery has revealed one of the molecular pathways involved.’
Professor Spector's team analysed blood samples donated by more than 6,000 twins.
Scientists found 22 metabolites, small molecules linked to metabolism, that may be indicators of how we will age. Some are strongly linked to birth weight suggesting this can be an important factor in health later in life
The researchers identified 22 metabolites directly linked to chronological age, with higher concentrations in older than in younger people.
Further work showed that the gene influencing levels of C-glyTrp could be modified by epigenetics, a process whereby environmental factors switch genes on or off and alter their activity.
The epigenetic changes may influence metabolism during a person's lifetime, thereby affecting susceptibility to age-related diseases.
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