First 3D Printed Organ Expected Next Year... -
Approximately 18 people die every day waiting for an organ transplant. But that may change someday sooner than you think -- thanks to 3D printing.
Advances in the 3D printing of human tissue have moved fast enough that San Diego-based bio-printing company Organovo now expects to unveil the world's first printed organ -- a human liver -- next year.
Like other forms of 3D printing, bio-printing lays down layer after layer of material -- in this case, live cells -- to form a solid physical entity -- in this case, human tissue. The major stumbling block in creating tissue continues to be manufacturing the vascular system needed to provide it with life-sustaining oxygen and nutrients.
Organovo, however, said it has overcome that vascular issue to a degree. "We have achieved thicknesses of greater than 500 microns, and have maintained liver tissue in a fully functional state with native phenotypic behavior for at least 40 days," said Mike Renard, Organovo's executive vice president of commercial operations.
A micron is one-millionth of a meter. To better understand the scale Renard is describing, think of it this way: A sheet of printer paper is 100 microns thick. So the tissue Organovo has printed is the thickness of five sheets of paper stacked on top of each other.
Printing hepatocytes -- the cells that make up most liver tissue -- isn't enough, however. There are multiple types of cells with different functions in tissue that must be combined to create a living human organ.
Organovo's researchers were able to bring together fibroblasts and endothelial cells, which perform the function of developing tiny vascular networks, allowing the company to achieve thick tissue with good cell viability, Renard said.
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Approximately 18 people die every day waiting for an organ transplant. But that may change someday sooner than you think -- thanks to 3D printing.
Advances in the 3D printing of human tissue have moved fast enough that San Diego-based bio-printing company Organovo now expects to unveil the world's first printed organ -- a human liver -- next year.
Like other forms of 3D printing, bio-printing lays down layer after layer of material -- in this case, live cells -- to form a solid physical entity -- in this case, human tissue. The major stumbling block in creating tissue continues to be manufacturing the vascular system needed to provide it with life-sustaining oxygen and nutrients.
Organovo, however, said it has overcome that vascular issue to a degree. "We have achieved thicknesses of greater than 500 microns, and have maintained liver tissue in a fully functional state with native phenotypic behavior for at least 40 days," said Mike Renard, Organovo's executive vice president of commercial operations.
A micron is one-millionth of a meter. To better understand the scale Renard is describing, think of it this way: A sheet of printer paper is 100 microns thick. So the tissue Organovo has printed is the thickness of five sheets of paper stacked on top of each other.
Printing hepatocytes -- the cells that make up most liver tissue -- isn't enough, however. There are multiple types of cells with different functions in tissue that must be combined to create a living human organ.
Organovo's researchers were able to bring together fibroblasts and endothelial cells, which perform the function of developing tiny vascular networks, allowing the company to achieve thick tissue with good cell viability, Renard said.
Read more -
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